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Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA

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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Brglez Mojzer E., Knez Hrni M., kerget M., Knez ., Bren U

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FOXO4-DRI vs MOTS-c FOXO4-DRI and MOTS-c represent two fundamentally different approaches to biological aging, targeting distinct hallmarks of the aging process