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Disulfide-cleavage-triggered chemosensors and their biological applications

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p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process

Although the insulinotropic activity of GLP-1 was identified over 30 years ago, the short half-life of native GLP-1 (approximately 2 min)attributed to rapid enzymatic degradation by dipeptidyl peptidase-IVimpeded its early therapeutic application in T2DM (111)

While mild cases usually show self-limitation, susceptible individuals may develop pathological myocardial hypertrophy, fibrosis, and eventually progress to dilated cardiomyopathy (DCM) ( Recent studies have shown that, as the cell with the highest density of mitochondria, impaired energy metabolism in cardiomyocytes is a key pathological basis of damaged myocardium, which brings about a series of significant changes in myocardial energy and substrate metabolism, leading to metabolic remodeling, where the myocardium preferentially shifts substrates from fatty acids to glucose for utilization, and involves abnormalities in oxidative phosphorylation and a decrease in high-energy phosphates, resulting in dysfunctions in myocardial function and structure ( LC is an essential compound that facilitates fatty acid metabolism, supports mitochondrial import of fatty acids through OCTN2 on the outer mitochondrial membrane, and regulates the balance between fatty acid and glucose oxidative energy supply, thereby promoting mitochondrial energy metabolism ( 2 Materials and methods 2.1 Animal experiment 2.1.1 Animals Twelve male Balb/c mice, aged 68 weeks and weighing 2025 g, with SPF grade, were purchased from the Animal Experiment Centre of Three Gorges University, with production license No