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By activating both macro- and chaperone-mediated autophagy, GLP-1 could protect hepatocytes from fatty acid-related apoptosis by suppressing a dysfunctional ER stress response

In addition to monitoring weight loss and nutritional statues, future clinical trials should measure nausea and emesis following activation of central GLP-1-producing circuits as these adverse effects are the main reason cited for discontinuation of GLP-1R agonist pharmacotherapy 29,39

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State Lyophilized (powder) Storage Room temperature Duration Tolerated for shipping/transit windows of weeks