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An animal intervention study by Everard et al., 2013 presents moderate risk of bias, primarily due to small sample sizes and incomplete reporting of allocation concealment

As spotlighted in Februarys Nature Reviews Drug Discovery, in which Lees myostatin discovery and ensuing investigations over the next three decades are featured, there are clinical trials of at least 10 drugs either underway or soon launching that target myostatin and the related protein activin A or their receptors in varied ways or with a combination of drugs, with even more clinical trials rapidly evolving

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Variables We included the following patient sociodemographic, lifestyle and clinical variables (see Table 1): age (18 to 44 years