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Under physiological conditions, astrocytes support synaptic transmission by efficiently clearing glutamate via excitatory amino acid transporters (EAAT)1/2 106 , converting it into glutamine and supplying lactate to neurons through aerobic glycolysis 107

ConcentrationEfficacy Relationships The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with opioid agonists

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Zueco JA, Esquifino AI, Chowen JA, Alvarez E, Castrillon PO, Blazquez E

(2010) found that new behaviors take a median of 66 days of consistent repetition to become automatic, though the range extends considerably in each direction depending on the behavior and the person