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Pharmacodynamic Assessment From a pharmacokinetic standpoint, the two compounds do not share metabolic enzymes

71,72,73,74,75 Consequently, AZD3965, an MCT1 (monocarboxylate transporter 1) inhibitor, has emerged as the first lactate metabolism-targeting drug currently undergoing a phase I/II clinical trial (NCT01791595) for the treatment of advanced solid tumors and non-Hodgkin lymphoma

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Methods In this review, the following keywords including carotenoid, astaxanthin, lycopene, -carotene, lutein, crocin, crocetin, hypertension, blood pressure, vasodilation, were used for search in Web of Science, PubMed, Scopus, and Google Scholar databases

doi:10.3389/fpsyt.2021.671151 13