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Ipamorelin Research Ipamorelin was first characterized as a pentapeptide that releases growth hormone from primary rat pituitary cells with a receptor profile comparable to GHRP-6, while leaving ACTH, cortisol, prolactin, and thyroid-stimulating hormone levels largely unchanged in the models tested [1]

Ipamorelin effectively stimulates growth hormone release without affecting cortisol levels, minimizing side effects

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It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood

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