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Receptor internalisation was calculated from the loss of fluorescence intensity at the plasma membrane after 10 minutes of exendin-4 stimulation compared to baseline intensity for cells, or from the loss of fluorescence intensity after 5 minutes of exendin-4 stimulation versus vehicle for islets

[PubMed] [Google Scholar] 44.Schirra J, Sturm K, Leicht P, et al

Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects

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doi:10.2174/1573403X1604201229115531 Stumvoll M, Goldstein BJ, van Haeften TW