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2 Epigenetic allostasis model As an inescapable factor of the natural world, stress plays a pivotal role in the adaptive and maladaptive responses to the environment through epigenetic mechanisms [1, 18]

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Pre-clinical studies have reported that NAFLD is associated with lower concentrations of DA (and/or higher concentrations of DA metabolites) in the brain, suggesting a link between DA and NAFLD (Erba et al., 2015