Furthermore, the chronic inflammation and immune dysregulation seen in Long COVID and mast cell activation syndrome (MCAS) create a highly toxic environment for the mitochondria
Because longterm human studies are lacking, there are concerns about unknown immune, cardiovascular, or proliferative effects, and some experts warn that users may face unpredictable risks, especially with unsupervised use
Adv Cancer Res (2017) 136:10938
In particular, the antidepressants fluoxetine (Prozac and Sarafem) and paroxetine have the ability to greatly reduce the effectiveness of tamoxifen as they are strong inhibitors of CYP2D6, therefore they should not be prescribed in conjunction with tamoxifen
Since tirzepatide already activates the GLP-1 receptor along with the GIP receptor, combining it with semaglutide could overstimulate these pathways