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Conversely, upregulation of the anti-apoptotic protein MCL1 has been linked to acquired resistance against sorafenib-induced ferroptosis, revealing a potential adaptive mechanism (130)

Neuroreport 7:20132017 Zschocke J, Bayatti N, Clement AM, Witan H, Figiel M, Engele J, Behl C (2005) Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions

For instance, pathways involving mechanotransduction, where mechanical signals are converted into biochemical responses, play a significant role in muscle adaptation

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Among these organs, the liver stands out for its high degree of rhythmic transcriptional and metabolic activity, positioning it as a key mediator of whole-body metabolic homeostasis (24)