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1 Sunvold GD, Tetrick MA, Davenport GM, Bouchard GF

The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

Suppression of GST-P by treatment with glutathione-doxorubicin conjugate induces potent apoptosis in rat hepatoma cells

Revision of the ARE consensus sequence

Such deficiencies contribute to mitochondrial disorders, including Leigh syndrome, as well as neurodegenerative diseases such as Parkinsons and Alzheimers disease 19,20,21