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Though the patient was limited to 8-weeks of HP/TAZ treatment as part of the clinical trial design, treatment with HP/TAZ for up to 1 year (maximum 24 weeks of continuous use) in an open-label, long-term study (NCT02462083) has demonstrated a favorable safety profile

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(2) Transsulfuration which is the production of cysteine by Hcy with the assistance of vitamin B6, catalyzed by cystathionine--synthase (CBS)

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The fact that TMV-infected tobacco lines expressing nahG display elevated induction of PR-1 genes at 5 DAI is in line with recent results, showing enhanced expression of NtPR-1b and NtPR-1c in NahG tobacco in later stages of TMV infection (7 DAI) as compared to wild type ( AtPR-1 was also shown in an SA-deficient NahG biotype of A