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Severe hypoglycemia was not reported, and gastrointestinal events were the most frequent adverse effects in the tirzepatide group ( Tirzepatide was compared to once-weekly oral semaglutide in the SURPASS-2 study, an open-label, phase 3 clinical trial with a 40-week follow-up that enrolled T2DM patients with a BMI of 25 kg/m 2 and an HbA1c of 710.5% despite taking at least a 1500 mg dose of metformin

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GLP-1RA can also play a cardioprotective role by increasing autophagy, inhibiting cardiomyocyte apoptosis, reducing the expression of inflammation-related proteins (30), reducing cardiomyocyte apoptosis induced by hyperglycemia (31), and improving myocardial energy metabolism

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