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In a review of the role of glutathione in protection against neuronal death, Bains et al

The reversible thiolation of proteins is known to regulate several metabolic processes including enzyme activity, transport activity, signal transduction and gene expression through redox-sensitive nuclear transcription factors such as AP-1, NF-kappaB (NF-kB) and p53 [21, 23]

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However, according to the studies, compulsive smokers are firstly exposed to gradual accumulation of the damaging effects of damage caused by free radicals, which is most likely caused by the dysfunction of systems eliminating them (Isik et al., 2007