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For example, HRD1-mediated ERAD of pre-B-cell receptor (BCR) is essential for B-cell development and determines pre-BCR abundance, attenuating pre-BCR-driven signaling during the transition from the large to small pre-B-cell stage

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance