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15 mg: the maximum dose The highest approved dose produces the greatest average weight loss, 22.5% in SURMOUNT-1, but the incremental benefit over 10 mg is modest

However, BDF treatment notably upregulated c-kit expression, likely due to its protective effects on intestinal wall cells, as BDF also repaired the damaged intestinal barrier in rats

The present study observed reduced expression of 25-hydroxylase enzymes and 1--hydroxylase, vitamin D receptor, and increased expression of the 24-hydroxylase enzyme in the livers of HFD-fed mice

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