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Some of these studies have found a relationship between the BDNF polymorphism and brain morphology but not the disease state itself, whereas others have associated it with bipolar etiology only through an interaction with stressful life events ( Genes regulating glycogen synthase kinase-3 (GSK-3), a pro-apoptotic (programed cell death) peptide and a functional opponent of proteins involved in neuronal plasticity development, differentiation, and cytoskeletal assembly, have also been implicated in bipolar etiology