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Unlike COMT Val158Met where Met/Met homozygotes have reduced but not absent enzyme activity GSTM1 null and GSTT1 null represent complete enzymatic absence rather than reduced function

Pyruvate carboxylase deficiency is caused by a mutation in the PC gene (11q13.4-q13.5)

Women who have suffered multiple miscarriages tend to develop cardiometabolic diseases more often and at earlier ages than other women

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Dysbiosis and intestinal barrier failure trigger a systemic cytokine storm that drives microglial activation and dysregulates the neurotoxic kynurenine pathway, effectively remodeling the central neurochemical environment