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Mass spectrometric-based quantitation of protein amide hydrogen exchange for deuterons from heavy water buffers can detect perturbations in a protein's conformational ensemble in response to ligand binding [15], [16]

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doi: 10.1056/NEJMoa2403347 12 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al