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A randomised clinical trial has shown that supplementation with spermidine results in a beneficial effect on memory function or other neuropsychological, behavioural, or physiological parameters [193]

A prospective observational study in over 4,000 participants of the Framingham Heart Study and the Framingham Offspring Study with or without preexisting cardiovascular disease found no statistically significant association between vitamin E supplement intake and cardiovascular or all-cause mortality after a 10-year follow-up period (124)

A concentration of around 1% to 2% is often recommended for those new to GHK-Cu