The mechanisms behind MOTS-c are fascinating, but the peptide has a notable lack of long-term safety data
Several studies in murine models have demonstrated that DZN disrupts the activity of antioxidant enzymes, particularly glutathione peroxidase, which plays a critical role in renal metabolism [43]
Bajic, V.P., et al., Glutathione Redox Homeostasis and Its Relation to Cardiovascular Disease
[DOI] [PubMed] [Google Scholar] [144].Lee E, Choi A, Jun Y, Kim N, Yook JI, Kim SY, Lee S, Kang SW, Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling
These mechanisms help explain the diverse biological responses observed in preclinical models