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In this article, we aim to review the management of HE, starting with the efficacy and limitations of traditional agents with a focus on the evidence supporting newer therapies in HE (Table 1)

Bariatric surgeryparticularly the sleeve gastrectomy and gastric bypasshas long been considered the most effective treatment for obesity

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Patients seeking maximum weight reduction often gravitate toward tirzepatide's dual-mechanism advantage, while those prioritizing lower entry cost or proven long-term safety may prefer semaglutide