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Firstly, similar to LDL, Lp(a) promotes atherosclerosis by entering the vessel wall leading to cholesterol deposition, inflammation and calcification [45]

This allows the B12 to bypass the digestive system and any malabsorption issues

This paradoxical phenomenon is known as the "levee effect" (White,1958 Burby, 2006 Ding et al., 2023)

Further, T2DM remains one of the most significant risk factors not only for the development of MASLD but also for the progression of liver fibrosis and the occurrence of liverrelated complications, including HCC (Leith et al., 2024

In the TRIUMPH-1 Phase 3 trial, participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks, and up to 30.3% at 104 weeks in the study extension