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In reference to the nature of ROS behavior as a double-edged sword, even though several studies have documented the benefits of antioxidant drugs for cancer therapies, none has been supported by solid trials performed on a large scale 153,154

doi: 10.1186/s12967-022-03296-9

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As shown in Figure 7 , UMAP clustering ( Figure 7A ) clearly identifies multiple cellular populations in healthy kidneysincluding endothelial cells (EC), fibroblasts (FIB), vascular smooth muscle cells/pericytes (VSM/P), immune cells (IMM), podocytes (POD), and proximal tubule cells (PT)establishing the cellular expression context of ferroptosis-related genes