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Given the central role of altered metabolism across virtually all major HCC etiologies, the development of potent pharmacotherapies that target metabolic dysfunction is an urgent priority

Interventions that restore normal chromatin organization in these cell types could potentially slow or reverse atherogenic processes

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Controlled Trial J Clin Endocrinol Metab 103(6):22912301 Zinman B, Bhosekar V, Busch R, Holst I, Ludvik B, Thielke D, Thrasher J, Woo V, Philis-Tsimikas A (2019) Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial

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