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HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase

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doi:10.1016/j.jep.2013.04.038 78

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The C-terminal portion of the peptide ligand first engages the ECD through an alpha-helical interaction, forming an initial complex that positions the ligand for subsequent insertion of its N-terminal residues into the transmembrane domain (TMD)