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There were no other significant metabolic differences between the two arms at 6 and 12 months, except for an improvement in diastolic blood pressure in the placebo arm

Materials and methods Animal procedures To evaluate the effects of chronic feeding of ethanol liquid diets in a mouse model, 5-week-old C57BL/6 J male mice were purchased from The Jackson Laboratory (Bar Harbor, ME, USA) and maintained in the University of Nebraska Medical Center animal facility, following the NIH Guide for the Care and Use of Laboratory Animals

Protein Kinase C (PKC): Regulation and Biological Function

23 A phase 1 trial of NTLA-2001 demonstrated dose-dependent reductions in serum TTR, with reductions of 52% and 87% at low and high doses, respectively

cytosol) throughout the cell (Powers & Jackson, 2008)