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Of these rare syndromes, THMD3 (also called Amish-type microcephaly or Amish lethal microcephaly) has the more severe phenotype, resulting in a congenital microcephaly, elevated concentrations of -ketoglutarate in urine, and usually death in infancy (121)

Positive cell detection was used to quantify CC3 staining in tumour samples, calculated from DAB optical density mean

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