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Semaglutide is different in two important ways

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GLP-1 (Glucagon-Like Peptide-1) medications are a class of drugs initially developed to treat type 2 diabetes

Research highlights include: Long-Term Efficacy : Studies indicate that GLP-1 medications remain effective for weight loss over extended periods, with sustained reductions in body weight and improvements in glycemic control

It is a selective agonist of the ghrelin receptor (GHS-R1a) and is characterized by high selectivity in receptor-signaling assays without significant effects on other pituitary hormones