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Studies investigating the regulation of ion channels relevant to mitochondrial iron transport and cardiac dysfunction due to iron overload have demonstrated that the MCU facilitates the transport of Fe2 + into the mitochondria, while Mfrn2 may serve a regulatory function in this process [11]

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The following primary antibodies were used: anti-Gb3 (TCI chemicals, Japan, A2506, 1:1000 dilution), anti-LTL (Vector Labs, Burlingame, CA, FL1321, 1:1000 dilution), and anti-NPHS1 (R&D Systems, MN, USA, AF4269, 1:1000)

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