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A 2024 study published in JAMA Ophthalmology reported that patients with Type 2 diabetes who took semaglutide-containing medications had more than a fourfold higher risk for developing non-arteritic anterior ischemic optic neuropathy (NAION) compared with patients not on a GLP-1 agonist

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This pentadecapeptide demonstrates resistance to degradation in gastric juice, a property that distinguishes it from many therapeutic peptides that require modified administration routes to avoid gastric inactivation

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