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For understanding the stack this means: the order and the joint presence of both signals is mechanistically relevant, not just the sum of two individual doses

The mechanism is consistent

Its primary job is to get rid of histamine in the brain, uterus, skin, and liver

If excessive inflammation persists, it promotes subsequent deleterious effects, such as cellular damage and neurotoxicity (Peng et al., 2015

Intriguingly, Jnk hepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity