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Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)

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They generated inducible OL knockouts by crossing proteolipid protein 1-Cre recombinase-estrogen receptor T2 (Plp1-CreERT2) with Gipr floxed mice, triggered recombination with tamoxifen at postnatal day 60, and induced obesity with a 60% high-fat diet

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