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For weight management, NICE has appraised several licensed medicines that are available through NHS pathways or regulated private clinics: Semaglutide (Wegovy) NICE Technology Appraisal TA875 recommends semaglutide as an option for managing overweight and obesity in adults with a BMI of 35 kg/m or more (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when used within a specialist weight management service

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Patients should be counselled that sustainable weight management requires comprehensive lifestyle changes, and that injectable supplements are not a substitute for evidence-based interventions

It is most effective for the treatment of deep dimples and depressions of the buttocks and back of the thighs

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