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Taken together, UNC10415667 reveals that slightly larger benzaldehyde-based degraders can effectively recruit FBXO22 via C326 to promote the potent degradation of NSD2 without requiring chemical protection or bioactivation

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Compound 1 (6 g, 10.53 mmol) was dissolved in 50 mL MeOH with NaOH (2 g, 50 mmol) under ice bath conditions