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(PubMed) Dauncey MJ

Impaired gut barrier function, also referred to as a leaky gut, which may disrupt the balance between tolerance and immunity to non-self-antigens, is often observed in autoimmune diseases

A longer half-life often means: Less frequent dosing More stable blood levels Improved patient adherence Sustained therapeutic effects Because retatrutide has a half-life of approximately 6 days, researchers designed it as a once-weekly injection for obesity and type 2 diabetes treatment

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Researchers dont have all the answers yet, as to why leptin resistance occurs