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In terms of lowering HbA1c, dulaglutide, when administered once a week, was demonstrated to be more effective than exenatide twice a day, by 1.51% vs.0.99% [94]

This disparity is ascribed to variations in screening methodologies (eg, prevalent prostate-specific antigen [PSA] testing in affluent nations resulting in overdiagnosis), lifestyle determinants (eg, Western diets abundant in red meat and fat, obesity), aging demographics, and genetic predisposition (eg, elevated risk in populations of African descent)

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