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Peroxisome proliferator activated receptor ligands as anticancer drugs targeting mitochondrial metabolism

Glutathione is the most abundant intracellular thiol (i.e., a compound containing a sulfhydryl [SH] group) and low molecular weight tripeptide found in living cells

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Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage

Continuous stimulation has been theorized to lead to receptor desensitization, whereas intermittent signaling may preserve responsiveness