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For individuals with type 2 diabetes, this dual action improves glucose control alongside weight reduction

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Excess metabolites induce hepatocyte stress, injury and death, which subsequently leads to hepatic insulin resistance, changes in the gut microbiota, and other harmful phenomena, such as mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, and the generation of reactive oxygen species (ROS)

13 In this review, we summarise the evidence related to the effects of GLP-1 RAs on these outcomes ( Figure 1 ), which may shed light on the potential of these agents to be used in the clinical care of HF patients and investigated in large clinical trials to evaluate clinical outcomes

The continuous drip of bile into the small intestine can sometimes cause food to move too quickly through the tract