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It includes proteins and molecules involved in tissue architecture, signalling, support and remodelling
Appropriate for aggressive treatment of serious conditions or when multiple mechanisms clearly relevant
Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy
For example, coupling of MORs to G protein-gated inwardly rectifying potassium [GIRK, GIRK isoform (Kir3)] channels in the presence of an efficacious agonist such as [Met] 5 enkephalin (ME) leads to homologous desensitization, because the sensitivity of closely related G protein-coupled receptors (GPCRs) such as the 2 -adrenoceptor, somatostatin, or orphanin-FQ (ORL) receptors is unaffected
A., Zhang, X
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