The meta-analysis revealed that compared to other administration routes of vitamin B12, acupoint injection significantly improved the clinical effectiveness proportion by 28% (risk ratio [RR] 1.28, 95% confidence interval [CI] 1.221.35), peroneal nerve motor nerve conduction velocity (MNCV) by 4.43 m/s (MD 4.43, 95% CI 2.836.03), peroneal nerve sensory nerve conduction velocity (SNCV) by 3.82 m/s (MD 3.82, 95% CI 3.234.41), median nerve MNCV by 5.48 m/s (MD 5.48, 95% CI 4.716.24), and median nerve SNCV by 4.62 m/s (MD 4.62, 95% CI 3.845.39) in patients with DN, while having no significant impact on fasting blood glucose (FBG) (MD 0.18, 95% CI 0.44 to 0.08), 2-h postprandial blood glucose (2h-PBG) (MD 0.02, 95% CI 0.36 to 0.33), and the adverse event incidence (RR 1.44, 95% CI 0.444.70)
HKD and AU acknowledge the support of Japan Science and Technology (JST) Agency, Japan toward Asia Youth Exchange Program in Science (Sakura Exchange Program)
Additionally, the limited supply of many of these products has increasingly shifted toward use in obesity treatment, driven by profit motives, leaving many type 2 diabetes patients unable to access medications they rely upon
Further work should determine the true contribution of TauT to muscle carnosine increases with BA supplementation
(2019) 39:e0060118
