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[15] [16] The scientific evidence examining the relationship between GLP-1 receptor agonists and suicidal ideation remains limited but largely reassuring

Its compounding-pathway status shifted in April 2026 when the FDA removed it from Category 2 of the 503A bulk substances list, though this is a compounding determination, not an approval

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The researchers note that the apparent excess risk was concentrated in older adults, men, and people with more advanced diabetes or eye or cardiovascular conditions

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