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A 2023 analysis of semaglutide trials found that 68 weeks of semaglutide 2.4 mg was associated with a 0.5% reduction in hip BMD compared to 0.1% with placebo [38]

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These additionally internalized receptors are for the most part dimerized with MC3R (Schellekens et al., 2013), suggesting that dimerization with MC3R may not only lead to reduced efficiency of GHSR1a signaling, but also to reduced surface expression of the receptor