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Mutant mice were born with red, shiny skin that rapidly dried and died, lacking typical ichthyosiform lesions ( Alox12b loss-of-function mutant mouse skin grafts can develop local ichthyosiform manifestations when matured on nude mice

Martinet A, et al

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

Filardo, G

Zacharias N, Sailhamer EA, Li Y, Liu B, Butt MU, Shuja F, et al