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Its important to consider that patients taking GLP1-RA may have other comorbidities that can contribute to palpitations/arrhythmias such as GI symptoms leading to electrolyte imbalances, diabetes, chronic kidney disease, and a weakened heart muscle (heart failure), says Dr

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Individuals with certain genetic predispositions may retain muscle more easily during weight loss, while others may need to be more deliberate about protein and strength training

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This led to clinical trials for the use of Rybelsus (oral semaglutide) specifically for weight loss