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Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 ( The anorectic effects of GLP-1 can also be explained by its GABAergic modulation in the nucleus tractus solitarius (NTS) cells

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Interestingly, our in silico database search of enriched ABR genes had hits to the Gram-negative bacteria family of Enterobacteriaceae and in some cases specific genera of Salmonella , Escherichia , Klebsiella , Shigella , Enterobacter and Citrobacter

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