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The mean reductions in the treated groups were 35.4% for the supplement, 38.8% for the lotion, and 31.0% for the supplement-plus-lotion combination

doi: 10.1038/cr.2010.46 Summary Keywords Epac, exendin-4, GLP-1 receptor, methylglyoxal, mitochondrial dysfunction, oxidative stress Citation Nuamnaichati N, Mangmool S, Chattipakorn N and Parichatikanond W (2020) Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway

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Author contributions All authors analyzed the data described in this letter and discussed their signifacances

Wegovy, approved in December 2022, was the latest to be authorised, following Saxenda (liraglutide, a drug that targets the same GLP-1 receptor as Wegovy) in July 2022 and Qsymia (a combination of phentermine and topiramate) in 2020