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[33] The cells need for NADPH, ribose 5-phosphate, and ATP From a molecular point of view, the fate of glucose 6-phosphate depends largely on the relative activities of the enzymes that metabolize it through glycolysis and the pentose phosphate pathway, particularly phosphofructokinase-1 (PFK-1

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Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

doi: 10.1016/j.drudis.2020.05.001 13 CarliniV

These findings are mechanistically coherent with GHK-Cus anti-inflammatory NF-kB activity because the secondary injury cascade in SCI involves microglial activation, sustained pro-inflammatory cytokine release, and reactive oxygen species generation