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The muscle preservation benefits accumulate over time and are most apparent after 8-12 weeks of consistent use combined with resistance training

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A logical target whereby metformin could mediate its putative antiproliferative effects in cancer is via inhibition of mTOR and the serine-threonine kinase, ribosomal S6K (pS6K), either via activation of AMPK or via an AMPK-independent pathway (241, 242)